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RESEARCH PRODUCT

Precision medicine in breast cancer: reality or utopia?

Jingxuan ShanFrançois GhiringhelliStéphanie PlenchetteStéphanie PlenchetteAli BettaiebAli BettaiebLotfi ChouchaneCatherine PaulCatherine Paul

subject

HER2+0301 basic medicineTumor heterogeneitymedicine.medical_specialtyPathologyMolecular subtypeslcsh:MedicineBreast NeoplasmsReviewCancer VaccinesTumor heterogeneityGeneral Biochemistry Genetics and Molecular BiologyGenetic Heterogeneity03 medical and health sciencesBreast cancer0302 clinical medicineBreast cancer[ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathologyHumansChemotherapyMedicineMedical physicsTriple negativebusiness.industrylcsh:RPrecision medicineCancerGeneral MedicinePrecision medicinemedicine.disease3. Good health030104 developmental biology030220 oncology & carcinogenesisNeoplastic Stem CellsTriple-negativeFemaleImmunotherapyPhase III clinical trialsbusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

description

International audience; Many cancers, including breast cancer, have demonstrated prognosis and support advantages thanks to the discovery of targeted therapies. The advent of these new approaches marked the rise of precision medicine, which leads to improve the diagnosis, prognosis and treatment of cancer. Precision medicine takes into account the molecular and biological specificities of the patient and their tumors that will influence the treatment determined by physicians. This new era of medicine is accessible through molecular genetics platforms, the development of high-speed sequencers and means of analysis of these data. Despite the spectacular results in the treatment of cancers including breast cancer, described in this review, not all patients however can benefit from this new strategy. This seems to be related to the many genetic mutations, which may be different from one patient to another or within the same patient. It comes to give new impetus to the research-both from a technological and biological point of view-to make the hope of precision medicine accessible to all.

https://doi.org/10.1186/s12967-017-1239-z