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RESEARCH PRODUCT
Dose-dependent impairing effects of morphine on avoidance acquisition and performance in male mice.
María A. AguilarVicente M. SimónJosé Miñarrosubject
MaleNarcoticsTime FactorsCognitive Neurosciencemedicine.medical_treatmentDose dependenceMale miceExperimental and Cognitive PsychologyPharmacologyLocomotor activityDevelopmental psychologyBehavioral NeuroscienceMicemedicineAnimal activityAvoidance LearningAnimalsMice Inbred BALB CBehavior AnimalDose-Response Relationship DrugMorphineStimulantDose–response relationshipMorphinePsychologyNeurosciencemedicine.drugdescription
The effects of morphine (6.3, 12.6, and 25.2 mg/kg) on active avoidance behavior of BALB/C mice are explored in three acquisition sessions and in two subsequent performance sessions. Morphine-treated animals showed an increase in avoidance acquisition with respect to control group without differences in performance. However, a dramatical, concomitant rise in the locomotor activity of the animals (increase in the number of crossings during the intertrial intervals) prompted us to transform the data employing a formula with which a measure of actual learning was obtained. Applying this formula, we have observed that morphine administration impairs, dose-dependently, acquisition and performance of avoidance. Thus, the impairing effects of morphine on avoidance could be masked by their stimulant effects on locomotor activity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-06-10 | Neurobiology of learning and memory |