The consequences of regulation of desat1 expression for pheromone emission and detection in Drosophila melanogaster.

6533b838fe1ef96bd12a531e

RESEARCH PRODUCT

The consequences of regulation of desat1 expression for pheromone emission and detection in Drosophila melanogaster.

François Bousquet Benjamin Houot Jean-françois Ferveur

subject

Fatty Acid Desaturases Male Transcription Genetic [ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition MESH : Animals Genetically Modified MESH : Genotype MESH: Genotype Animals Genetically Modified Sexual Behavior Animal MESH : Hydrocarbons MESH: Reverse Transcriptase Polymerase Chain Reaction MESH : Drosophila melanogaster Drosophila Proteins MESH: Animals MESH : Female MESH: Sexual Behavior Animal Sex Attractants Genetics MESH: Nursing Assessment MESH : Craniocerebral Trauma biology MESH : Gene Expression Regulation Reverse Transcriptase Polymerase Chain Reaction MESH : Fatty Acid Desaturases MESH : Reverse Transcriptase Polymerase Chain Reaction MESH: Fatty Acid Desaturases MESH: Gene Expression Regulation Phenotype MESH: Intracranial Pressure MESH: Sex Attractants Drosophila melanogaster Sex pheromone Pheromone Female Drosophila melanogaster MESH : Mutation MESH: Mutation Genotype MESH : Coma MESH: Drosophila Proteins MESH : Male MESH: Craniocerebral Trauma Sensory system Locus (genetics)Investigations MESH: Drosophila melanogaster MESH: Animals Genetically Modified MESH: Hydrocarbons MESH: Education Nursing Continuing Genetics MESH : Nursing Assessment Animals MESH : Sexual Behavior Animal Gene MESH: Coma Transcriptional activity MESH : Sex Attractants MESH: Humans MESH: Transcription Genetic MESH : Humans MESH : Transcription Genetic biology.organism_classification MESH : Drosophila Proteins MESH: Male Hydrocarbons MESH : Intracranial Pressure Gene Expression Regulation Mutation MESH : Animals MESH : Education Nursing Continuing MESH: Female [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition

description

AbstractSensory communication depends on the precise matching between the emission and the perception of sex- and species-specific signals; understanding both the coevolutionary process and the genes involved in both production and detection is a major challenge. desat1 determines both aspects of communication—a mutation in desat1 simultaneously alters both sex pheromone emission and perception in Drosophila melanogaster flies. We investigated whether the alteration of pheromonal perception is a consequence of the altered production of pheromones or if the two phenotypes are independently controlled by the same locus. Using several genetic tools, we were able to separately manipulate the two pheromonal phenotypes, implying that desat1 is the sole gene responsible, exerting a pleiotropic effect on both transmission and detection. The levels of the five desat1 trancripts, measured in the head and body of manipulated flies, were related to variation in pheromone production. This suggests that the pleiotropic action of desat1 on pheromonal communication depends on the fine regulation of its transcriptional activity.

year	journal	country	edition	language
2010-08-01

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-00761517