6533b839fe1ef96bd12a596f

RESEARCH PRODUCT

Tumor Oxygenation and Its Relevance to Tumor Physiology and Treatment

Michael HöckelPeter Vaupel

subject

Therapy Outcomemedicine.medical_specialtyNeedle electrodeTissue oxygenationMetastatic lesionsTumor hypoxiabusiness.industrymedicineIn patientClinical significanceRadiologyTumor Oxygenationbusiness

description

For many years, the identification of tumor hypoxia, its systematic characterization and the assessment of its clinical relevance were not possible due to lack of methods suitable for the routine measurement of intratumoral oxygen tensions in patients. In the late 1980s, a novel and clinically applicable standardized procedure was established enabling the determination of the tissue oxygenation status in primary tumors, local recurrences, and metastatic lesions in patients using a computerized polarographic needle electrode system. Within a relatively short period of time, the significance of tumor oxygenation for therapy outcome became evident in numerous experimental and clinical studies.

https://doi.org/10.1007/978-1-4615-0205-0_8