6533b839fe1ef96bd12a5a8b
RESEARCH PRODUCT
Cancer phototherapy in living cells by multiphoton release of doxorubicin from gold nanospheres
Stefano LuinValerio VolianiValerio VolianiFabio BeltramPaolo FaraciOrazio VittorioOrazio VittorioGiovanni SignoreJulia Pérez-prietosubject
Materials scienceTherapeutic actionBiomedical EngineeringCancerNanotechnologyGeneral ChemistryGeneral MedicineConjugated systemGold nanospheresmedicine.diseaseDrug deliveryCancer cellmedicineGeneral Materials ScienceDoxorubicinNanocarriersmedicine.drugdescription
Doxorubicin is a widely used but toxic cancer chemotherapeutic agent. In order to localize its therapeutic action and minimize side effects, it was covalently conjugated to peptide-encapsulated gold nanospheres by click-chemistry and then photo-released in a controlled fashion by a multiphoton process. Selective treatment of a chosen region in a 2D layer of U2Os cancer cells is shown by driving photorelease with 561 nm irradiation at mu W power. These results show promising directions for the development of practical applications based on nanocarriers that can ensure drug delivery with high spatial and temporal control.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-04-09 |