6533b839fe1ef96bd12a5aa2

RESEARCH PRODUCT

An association analysis to identify genetic variants linked to asthma and rhinoconjunctivitis in a cohort of Sicilian children

Salvatore FasolaGiuliana FerranteGregorio SeiditaFabio CibellaStefania La GruttaStefania La GruttaGiovanni ViegiGiovanna CilluffoRiccardo AlessandroRiccardo AlessandroGianluca SottileMarta Torregrossa

subject

MaleCandidate genemedicine.medical_specialtyAdolescentSingle-nucleotide polymorphismSicilian childrenPolymorphism Single NucleotideCohort Studies03 medical and health sciences0302 clinical medicine030225 pediatricsInternal medicineGenetic variationmedicineotorhinolaryngologic diseasesGeneticsHumans030212 general & internal medicineChildLetter to the EditorGenetic Association StudiesGenetic associationAsthmaRhinitisbusiness.industrylcsh:RJ1-570Asthma Rhino-conjunctivitis Sicilian children Genetics SNPslcsh:Pediatricsmedicine.diseaseConjunctivitislanguage.human_languageAsthmaRhino-conjunctivitisItalyCohortlanguageFemalebusinessSicilianCohort studySNPs

description

Abstract Asthma and rhino-conjunctivitis are common chronic diseases in childhood. In this cross-sectional study, we performed a gene association analysis with current asthma and rhino-conjunctivitis in a cohort of Sicilian children aged 10–15 years. Overall, our findings reveal the importance of different genetic variants at 4p14, 16p12.1, 17q12, 6p12.2 and 17q21.1, identifying possible candidate genes responsible for susceptibility to asthma and rhino-conjunctivitis.

yearjournalcountryeditionlanguage
2018-10-22
10.1186/s13052-019-0603-4http://hdl.handle.net/10447/336947