6533b839fe1ef96bd12a5b55
RESEARCH PRODUCT
p Natural polyphenols as anti-inflammatory agents p
V. PellitteriSalvatore AccomandoGiovanni Corsellosubject
Anti-Inflammatory AgentsDiseaseHuman leukocyte antigenProtein Serine-Threonine KinasesModels BiologicalAntioxidantsGeneral Biochemistry Genetics and Molecular BiologyPathogenesisPhenolsmedicineHumansFlavonoidsInflammationchemistry.chemical_classificationAutoimmune diseaseMolecular StructureGeneral Immunology and Microbiologybusiness.industryPolyphenolsnutritional and metabolic diseasesGluten intolerancemedicine.diseaseGlutendigestive system diseasesFood intolerancechemistryCyclooxygenase 2ImmunologyCyclooxygenase 1Gluten freebusinessdescription
Celiac Disease is a worldwide spread condition affecting 1:100-1:200 individuals. It is a permanent food intolerance to ingested gluten in genetically predisposed subjects. In this review we analyze the biochemical markers of the disease going from laboratory findings to histology passing through genetics. Gluten intolerance is a unique model of autoimmune disease in which we can recognize the main environmental factor (gluten) and the more complex genetic background. In additional way, serological markers for monitoring the disease and a safe and effective therapy (gluten free diet) are also available. In deed the environmental factor such as gluten intake is necessary to trigger the disease but genetics also matter. HLA genes are the most studied but in recent times also not HLA related genes are giving proof of additional relative risk to disease if present. From histological point of view intra epithelial cell infiltration by several lymphocyte subsets is becoming more and more important also for understanding pathogenesis of the disease.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-12-29 | Frontiers in Bioscience |