6533b839fe1ef96bd12a63c6
RESEARCH PRODUCT
Influence of the differentiation system on the analytical parameters for the spectrophotometric determination of clonazepam in urine
Amparo SalvadorM. De La GuardiaFrancisca Randez-gilsubject
Detection limitAccuracy and precisionChromatographymedicine.diagnostic_testSpectrometerChemistryAnalytical chemistryUrineDiode arrayAnalytical ChemistrySpectrophotometrymedicineSensitivity (control systems)SpectroscopyDerivative spectroscopydescription
Abstract Electronic and mathematical differentiation of the ultraviolet visible spectra were compared from the study of the analytical parameters of the direct determination of clonazepam in urine samples. Third-order derivative spectra were used. The mathematical differentiation provides higher sensitivity, a lower limit of detection, and better accuracy and precision than the electronic one. The use of a diode array instrument provides lower sensitivity than that found using a conventional spectrometer; however, the limit of detection obtained in both cases is of the same order.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-12-01 | Microchemical Journal |