6533b839fe1ef96bd12a64b8
RESEARCH PRODUCT
Harnessing the potential of noninvasive in vivo preclinical imaging of the immune system: challenges and prospects.
Stefanie PektorMatthias MiedererMustafa Dikensubject
0301 basic medicineFluorescence-lifetime imaging microscopyTumor targetingBiomedical EngineeringMedicine (miscellaneous)Contrast MediaBioengineeringDevelopmentBiologyPharmacologic interventionMalignant diseaseImmunomodulation03 medical and health sciences0302 clinical medicineImmune systemIn vivoNeoplasmsBioluminescence imagingAnimalsHumansGeneral Materials ScienceOptical ImagingMagnetic Resonance Imaging030104 developmental biology030220 oncology & carcinogenesisImmune SystemPositron-Emission TomographyImmunologyDisease ProgressionNeurosciencePreclinical imagingdescription
Preclinical imaging has become a powerful method for investigation of in vivo processes such as pharmacokinetics of therapeutic substances and visualization of physiologic and pathophysiological mechanisms. These are important aspects to understand diseases and develop strategies to modify their progression with pharmacologic interventions. One promising intervention is the application of specifically tailored nanoscale particles that modulate the immune system to generate a tumor targeting immune response. In this complex interaction between immunomodulatory therapies, the immune system and malignant disease, imaging methods are expected to play a key role on the way to generate new therapeutic strategies. Here, we summarize examples which demonstrate the current potential of imaging methods and develop a perspective on the future value of preclinical imaging of the immune system.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-10-01 | Nanomedicine (London, England) |