Comparative trial between the use of amoxicillin and amoxicillin clavulanate in the removal of third molars

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RESEARCH PRODUCT

Comparative trial between the use of amoxicillin and amoxicillin clavulanate in the removal of third molars

Alberto Garcia-perla-garcia Rosa Yañez-vico Elena Aced-jiménez Esther Arjona-gerveno José-luis Gutiérrez-pérez Fernando Iglesias-martin Daniel Torres-lagares Juan-david Gonzalez-padilla

subject

Molar Adult Male medicine.medical_specialty Complications Analgesic Odontología Amoxicillin-Potassium Clavulanate Combination Gastroenterology law.invention Postoperative Complications Randomized controlled trial law Internal medicine medicine Humans General Dentistry Beta-Lactamase Inhibitors AMOXICILLIN/CLAVULANATE business.industry Research Amoxicillin Bacterial Infections Amoxicillin :CIENCIAS MÉDICAS [UNESCO]Ciencias de la salud Surgery Anti-Bacterial Agents Third molars Diarrhea Otorhinolaryngology Clavulanate UNESCO::CIENCIAS MÉDICAS Tooth Extraction Surgery Female Molar Third Amoxicillin-Potassium Clavulanate Combination medicine.symptom Oral Surgery business beta-Lactamase Inhibitors medicine.drug

description

Objectives: The purpose of this study was to compare the use of amoxicillin (1g) vs amoxicillin and clavulanate (875/125mg) after extraction of retained third molars for prevention of infectious complications. Study Design: The study involved 546 patients attending for removal a retained third molar and divided in to two groups: Group 1 - amoxicillin and clavunate (875/125mg) group (n=257) and Group 2 - amoxicillin (1g) group (n=289). All patients were recalled for investigating the possibility of infection, presence of diarrhea and further analgesic intake. Results: From a total of 546 patients, the frequency of infection was 1.4%, without no statistically differences be - tween the two groups. Group 1 showed statistically higher presence of patients with gastrointestinal complications ( p>0.05). In 546 patients, 2.7% of patients reported severe pain that would not relieve with medication. Conclusions: The results of our study show that the use of amoxicillin (1g) and amoxicillin and clavunate (875/125mg) is similar efficacious in preventing infection after retained third molar extraction but amoxicillin and clavunate (875/125mg) produces more gastrointestinal discomfort.

year	journal	country	edition	language
2014-06-01	Medicina Oral, Patología Oral y Cirugía Bucal

10.4317/medoral.19778 http://europepmc.org/articles/PMC4259379