6533b839fe1ef96bd12a6571
RESEARCH PRODUCT
A PLE-based resolution of cocaine, pseudococaine, and 6- and 7-methoxylated cocaine analogues
Alan P. KozikowskiDaniele SimoniStefano ManfrediniPier Giovanni BaraldiIlaria Lamprontisubject
Resolution (mass spectrometry)ChemistryOrganic ChemistryClinical BiochemistryPharmaceutical ScienceBiochemistryEsterasePseudococaineEnzymatic hydrolysisDrug DiscoveryMolecular MedicineOrganic chemistryChemoselectivityMolecular BiologyPig liverdescription
Abstract The enzymatic hydrolysis of racemic cocaine and cocaine analogues using pig liver esterase (PLE) is shown to afford a practical means for achieving their chemical resolution. This reaction was found to proceed not only with good enantioselectivity, but with an interesting chemoselectivity as well.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-02-01 | Bioorganic & Medicinal Chemistry Letters |