Search results for "Pseudococaine"

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A PLE-based resolution of cocaine, pseudococaine, and 6- and 7-methoxylated cocaine analogues

1996

Abstract The enzymatic hydrolysis of racemic cocaine and cocaine analogues using pig liver esterase (PLE) is shown to afford a practical means for achieving their chemical resolution. This reaction was found to proceed not only with good enantioselectivity, but with an interesting chemoselectivity as well.

Resolution (mass spectrometry)ChemistryOrganic ChemistryClinical BiochemistryPharmaceutical ScienceBiochemistryEsterasePseudococaineEnzymatic hydrolysisDrug DiscoveryMolecular MedicineOrganic chemistryChemoselectivityMolecular BiologyPig liverBioorganic & Medicinal Chemistry Letters
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