6533b839fe1ef96bd12a65fe
RESEARCH PRODUCT
Protecting group-free radical decarboxylation of bile acids: Synthesis of novel steroidal substituted maleic anhydrides and maleimides and evaluation of their cytotoxicity on C6 rat glioma cells.
Mohammad SamadiAli Khalafi-nezhadThomas NuryGérard Lizardsubject
0301 basic medicineFree RadicalsDecarboxylationClinical BiochemistryAntineoplastic AgentsChemistry Techniques SyntheticBiochemistryDecarboxylationBile Acids and SaltsMaleimides03 medical and health scienceschemistry.chemical_compoundEndocrinologyGliomaCell Line TumormedicineOrganic chemistryAnimalsProtecting groupCytotoxicityMolecular BiologyMaleic AnhydridesPharmacologyChemistryOrganic ChemistryMaleic anhydrideGliomamedicine.diseaseRats030104 developmental biologyBarton decarboxylationDrug Screening Assays Antitumordescription
Abstract We report the first Barton radical decarboxylation of unprotected bile acids via in situ irradiation of their thiohydroxamic esters in the presence of citraconic anhydride and citracoimide, leading to the synthesis a series of steroidal maleic anhydrides and maleimides as novel hybrid bile acids. The cytotoxic activities were evaluated on C6 rat glioma cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-04-25 | Steroids |