6533b839fe1ef96bd12a6607

RESEARCH PRODUCT

Evidence for the importance of the human dopamine transporter gene for withdrawal symptomatology of alcoholics in a German population

Hans RommelspacherCatrin WernickeLutz G. SchmidtGeorg WintererMichael N. SmolkaJürgen Gallinat

subject

AdultMalemedicine.medical_specialtyGenotypeMolecular Sequence DataPopulationNerve Tissue ProteinsGene FrequencyPolymorphism (computer science)GermanyInternal medicineGenotypeOdds RatiomedicineHumansAlleleeducationDopamine transporterGeneticsDopamine Plasma Membrane Transport Proteinseducation.field_of_studyChi-Square DistributionMembrane GlycoproteinsPolymorphism GeneticbiologyGeneral NeuroscienceMembrane Transport ProteinsOdds ratioMiddle AgedSubstance Withdrawal SyndromeAlcoholismRestriction siteVariable number tandem repeatEndocrinologybiology.proteinFemale

description

Two new polymorphisms in the 3' untranslated region (3'UTR) of the dopamine transporter (DAT1) gene, adjacent to the known variable number of tandem repeats (VNTR) polymorphism, have been investigated in the present population-based association study including 351 alcoholics and 336 controls. The DraI restriction site was not polymorphic in our population. The G2319A polymorphism was not significantly different with respect to genotype or allele distribution between alcoholics and controls. Subsequently, in individuals with VNTR homozygosity for the ten repeat allele, we found a higher prevalence of A/A homozygosity in patients with seizure history (P = 0.001, odds ratio (OR) = 7.913), with delirium history (P = 0.032, OR = 4.707), and with an alcoholic mother (P = 0.021, OR = 5.250), compared to homozygote 10/10 controls. Our findings provide further evidence that the 3'UTR of the DAT1 gene affects vulnerability to severe alcohol withdrawal.

yearjournalcountryeditionlanguage
2002-11-01Neuroscience Letters
https://doi.org/10.1016/s0304-3940(02)00985-0