6533b839fe1ef96bd12a66fa
RESEARCH PRODUCT
Exosome-Mediated Signaling in Epithelial to Mesenchymal Transition and Tumor Progression
Alice ConigliaroCarla Cicchinisubject
0301 basic medicinelcsh:MedicineReviewExosomeMetastasis03 medical and health sciencesepithelial-mesenchymal plasticity; cancer-derived exosomes; extracellular vesicles; metastasis; tumor nicheGene expressionmedicinemetastasisEpithelial–Mesenchymal plasticityEpithelial–mesenchymal transitionbusiness.industrytumor nicheTransdifferentiationlcsh:RRNAGeneral Medicinemedicine.diseasecancer-derived exosomeMicrovesiclesCell biology030104 developmental biologyepithelial-mesenchymal plasticityTumor progressionmetastasiextracellular vesiclebusinesscancer-derived exosomesextracellular vesiclesdescription
Growing evidence points to exosomes as key mediators of cell–cell communication, by transferring their specific cargo (e.g., proteins, lipids, DNA and RNA molecules) from producing to receiving cells. In cancer, the regulation of the exosome-mediated intercellular communication may be reshaped, inducing relevant changes in gene expression of recipient cells in addition to microenvironment alterations. Notably, exosomes may deliver signals able to induce the transdifferentiation process known as Epithelial-to-Mesenchymal Transition (EMT). In this review, we summarize recent findings on the role of exosomes in tumor progression and EMT, highlighting current knowledge on exosome-mediated intercellular communication in tumor-niche establishment, migration, invasion, and metastasis processes. This body of evidence suggests the relevance of taking into account exosome-mediated signaling and its multifaceted aspects to develop innovative anti-tumoral therapeutic approaches.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-12-01 |