6533b839fe1ef96bd12a6d4d
RESEARCH PRODUCT
Search for New Antihistaminic Compounds by Molecular Connectivity
G.m. Antón-fosJorge GalvezR. Garcia-domenechM.j. DuartE Casabán-rossubject
Pharmacologychemistry.chemical_compoundSedative effectchemistryHydrochloridemedicineAntihistaminic drugsOrganic chemistryTerfenadineReference drugCombinatorial chemistrymedicine.drugdescription
In this paper it is demonstrated that by adequate selection of topological descriptors we can make possible the prediction of different pharmacological properties, such as plasmatic concentration or sedative effect, within a group of antihistaminic drugs. Moreover, also demonstrated is the usefulness of molecular connectivity in the search of new active compounds. Examples of such compounds are 4-(l-buthylpenthyl)pyridine, N-(3-bromopropyl)-phtalimide and N-(3-chlorpropyl)-piperidin hydrochloride. All of them show antihistaminic activity values more than 30% higher than that of terfenadine, which is used as the reference drug.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-01-01 | Quantitive Structure-Activity Relationships |