6533b839fe1ef96bd12a6d91

RESEARCH PRODUCT

TISSUE pH-DISTRIBUTION WITHIN MALIGNANT TUMORS AS MEASURED WITH ANTIMONY MICROELECTRODES

P. VaupelJ. BusseW. Müller-klieser

subject

chemistry.chemical_compoundMicroelectrodeMaterials sciencechemistryAntimonychemistry.chemical_elementSubstrate (chemistry)Distribution (pharmacology)Tumor tissueLactic acidBiomedical engineering

description

Publisher Summary Recent experiments using glass microelectrodes have demonstrated that very low tissue pH-values are prevalent in C3H mouse mammary carcinomas. The acidification of the tumor tissue is the result of an elevated lactic acid production and its inadequate removal. As a consequence of heterogeneities in tumor blood flow and in substrate supply, tissue pH values are distributed heterogeneously within solid tumors. Although glass microelectrodes with tip diameters of about 1 μm and a sensitive length of 10–50 μm have been used, the spatial resolution can be improved utilizing glass coated antimony microelectrodes the sensitive areas of that are restricted to their very tips. This chapter discusses a study in which the tissue pH-distribution within malignant tumors was measured with antimony microelectrodes. Antimony microelectrodes with tip diameters between 1 and 5 μ m were used in this study. Measurements were carried out on solid tumors of DS-carcinosarcoma, subcutaneously implanted into the thighs of rats.

yearjournalcountryeditionlanguage
1981-01-01
https://doi.org/10.1016/b978-0-08-027346-4.50066-8