6533b839fe1ef96bd12a6de4
RESEARCH PRODUCT
Resistance of Cancer Stem Cells to Cell-Mediated Immune Responses
Cecilia EleuteriGaia CampocciaCristina MaccalliMariangela ZaneVeronica CatalanoGiorgio StassiGiorgio ParmianiGianluca Giacobinisubject
Immune systemCancer stem cellDisease progressionCancer researchImmune escapePatient survivalEpigeneticsBiologyAcquired immune systemCell mediated immunitydescription
In the past decades, the hierarchical organization of tumors, governed by Cancer Stem Cells (CSCs), have been reported with regard to several tumor types. Advances in sequencing technologies have demonstrated that diverse genetic CSCs subclones, derived from the branching evolution, compete with each other within the tumor mass, thereby contributing to the functional heterogeneity. It is becoming increasingly clear that epigenetic modifications and microenvironmental influences are important determinants of tumor fitness resulting in disease progression, recurrence and reduced patient survival. Therefore, more effective therapies will require gaining insights into the role of genetic and non-genetic influences in coordinating tumor maintenance.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 |