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RESEARCH PRODUCT
HPMC-salicylate conjugates as macromolecular prodrugs: Design, characterization, and nano-rods formation
Muhammad Tahir HaseebMunair BadshahMuhammad Nawaz TahirSheshanath V. BhosaleWolfgang TremelMuhammad SherMohammad S. IqbalMuhammad Ajaz Hussainsubject
Polymers and PlasticsOrganic Chemistrytechnology industry and agricultureChemical modificationProdrugbody regionschemistry.chemical_compoundchemistryDistilled waterCovalent bondMaterials ChemistryOrganic chemistrySelf-assemblyDrug carrierSalicylic acidNuclear chemistryConjugatedescription
The design, characterization, and nano-rods formation of hydroxypropylmethylcellulose (HPMC)-salicylate conjugates as macromolecular prodrugs, was described. HPMC, obtained from Zhejiang Zhongbao Imp and Exp Corp, was dried under vacuum at 110°C for 8 hr. Nanoparticles were prepared using dialysis process in which 170 mg of HPMC-salicylate sample was dissolved in 5 mL of purified DMSO and was dialyzed against distilled water for 4 days. HPMC-salicylic acid conjugates reveal the absence of sulfur in all of the samples showing that there is no introduction to tosylate groups either covalently bounded or as an impurity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-07-08 | Journal of Polymer Science Part A: Polymer Chemistry |