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RESEARCH PRODUCT
Disease-Specific and Common HLA and Non-HLA Genetic Markers in Susceptibility to Rheumatoid Arthritis, Type 1 Diabetes Mellitus and Multiple Sclerosis
Nikolajs SjaksteJolanta KalninaTatjana SjaksteLiene Nikitina-zakeNatalia Paramonovasubject
0301 basic medicineType 1 diabetesbusiness.industryMultiple sclerosisGenetic enhancementHuman leukocyte antigenmedicine.disease03 medical and health sciencesMyelin030104 developmental biologymedicine.anatomical_structureAntigenRheumatoid arthritisDiabetes mellitusImmunologymedicinebusinessdescription
Autoimmune diseases cause numerous health and social problems throughout the world. The common spectrum of autoimmune diseases affect the majority of tissues within the body, including pancreatic beta cells in type 1 diabetes (T1DM), myelin surrounding nerve axons in Multiple sclerosis (MS) and synovial joint antigens in Rheumatoid Arthritis (RA). The diseases are likely caused by a complex interaction between multiple HLA- and non- HLA related genes and environmental factors. The well documented co-clustering of autoimmune diseases within families and individuals, together with apparent sharing of number risk genes between the diseases suggests at least some common mechanisms of autoimmune development.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 | Journal of Molecular and Genetic Medicine |