6533b83afe1ef96bd12a6f16
RESEARCH PRODUCT
Uremic serum inhibits monocyte-dependent, but not interleukin-2-dependent steps of T cell proliferation.
Hans KöhlerStefan MeuerHubert Dumannsubject
Interleukin 2AdultMalemedicine.medical_specialtyT cellT-LymphocytesLymphocyte ActivationMonocytesImmune toleranceImmune systemInternal medicinemedicineImmune ToleranceSuppressor Factors ImmunologicHumansAgedUremiabusiness.industryCell growthMonocyteT lymphocyteMiddle Agedmedicine.diseaseUremiamedicine.anatomical_structureEndocrinologyInterleukin-2businessmedicine.drugdescription
We examined the influence of uremic serum on antigen receptor triggered T cell proliferation in dialysis patients with impaired immune function, i.e., 12 nonresponders to hepatitis B vaccination. The dialysis patients showed a monocyte dysfunction and an increased responsiveness to interleukin 2 (IL-2) according to our previous findings. In vitro the addition of IL-2 completely reconstituted the defect. Uremic serum inhibited monocyte-dependent T cell proliferation of patients and of healthy controls. Contrary, monocyte-independent steps of T cell proliferation were not impaired by uremic serum. When IL-2 was added to cultures, the T cell proliferation in the presence of uremic serum was even enhanced. We conclude that uremic immunodeficiency may be enhanced by soluble factors present in uremic serum which inhibit monocyte-dependent steps of T cell proliferation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1990-01-01 | Nephron |