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RESEARCH PRODUCT
An Easy Assessment of Frailty at Baseline Independently Predicts Prognosis in Very Elderly Patients With Acute Coronary Syndromes.
Oriol AlegreFrancesc FormigaRamón López-palopFrancisco MarínMaría T. VidánManuel Martínez-sellésAntoni CarolAlessandro SionisPablo Díez-villanuevaJaime AboalAnna Palau-vendrelHéctor BuenoAngel Perez RiveraJuan SanchísEmad Abu-assiMiguel CorbíJuan C. CastilloJordi BañerasVioleta González-salvadoÀNgel CequierAlbert Ariza-soléOriol AlegreAlbert Ariza-soléJordi BañerasAgnes RafecasCinta LlibreMiquel VivesAlessandro SionisJaime AboalPau VilardellAlfredo BardajíCarlos TomásOscar MachoManuel PeraireAna LacalAnna PalauVanessa Martínez-garcíaNúria ComaAntoni CarolMarta CampreciósSusana HerranzSergi YunMaria OrriolsJosep Mª ViguerJuan Carlos CastilloVíctor BecerraPilar CardilaMiguel CorbíJavier López DíazHéctor García-pardoJose ÁNgel Perez-riveraAna Merino MerinoFrancisco Martín-herreroMaria Isabel GarcimartínJuan SanchísClara BonanadÓScar FabregatVícto Pérez-rosellóRamon López-palopMiguel Rodríguez-santamartaVioleta González-salvadoBernardo García De La VillaLuis AsmaratsJaume MaristanyJoan TorresMarta Gómez-llorenteMartín Jesús García-gonzálezRaquel PimientaAna Viana-tejedorIván Núñez-gilJuan Ruiz-garcíaAlejandro Cortés BeringolaHéctor BuenoManuel Martínez-sellésMariá T. VidánPablo Díez-villanuevaFrancisco MarínAitziber MunárrizNahikari Salterainsubject
Background informationMalemedicine.medical_specialtyTime FactorsFrail ElderlyEnfermedad cardiovascularAncianoComorbidityKaplan-Meier Estimate030204 cardiovascular system & hematologyRisk Assessment03 medical and health sciences0302 clinical medicineInternal medicineCause of DeathClinical endpointPrevalenceMedicineHumansIn patient030212 general & internal medicineProspective StudiesRegistriesAcute Coronary SyndromeGeneral NursingProportional Hazards ModelsAged 80 and overFramingham Risk ScoreEjection fractionbiologyFrailtybusiness.industryHealth PolicyMortality rateGeriatric assessmentGeneral MedicinePrognosisTroponinSurvival AnalysisSpainbiology.proteinCardiopatía coronariaFemaleGeriatrics and GerontologybusinessAncianosdescription
Background: Information about the impact of frailty in patients with acute coronary syndromes (ACS) is scarce. No study has assessed the prognostic impact of frailty as measured by the FRAIL scale in very elderly patients with ACS. Methods: The prospective multicenter LONGEVO-SCA registry included unselected patients with ACS aged 80 years or older. A comprehensive geriatric assessment was performed during hospitalization, including frailty assessment by the FRAIL scale. The primary endpoint was mortality at 6 months. Results: A total of 532 patients were included. Mean age was 84.3 years, 61.7% male. Most patients had positive troponin levels (84%) and high GRACE risk score values (mean 165). A total of 205 patients were classified as prefrail (38.5%) and 145 as frail (27.3%). Frail and prefrail patients had a higher prevalence of comorbidities, lower left ventricle ejection fraction, and higher mean GRACE score value. A total of 63 patients (11.8%) were dead at 6 months. Both prefrailty and frailty were associated with higher 6-month mortality rates (P < .001). After adjusting for potential confounders, this association remained significant (hazard ratio [HR] 2.71; 95% confidence interval [CI] 1.09–6.73 for prefrailty and HR 2.99; 95% CI 1.20–7.44 for frailty, P = .024). The other independent predictors of mortality were age, Charlson Index, and GRACE risk score. Conclusions: The FRAIL scale is a simple tool that independently predicts mortality in unselected very elderly patients with ACS. The presence of prefrailty criteria also should be taken into account when performing risk stratification of these patients. Sin financiación 4.899 JCR (2018) Q1, 6/53 Geriatrics & Gerontology 2.123 SJR (2018) Q1, 2/152 Nursing (miscellaneous), 6/114 Geriatrics and Gerontology, 9/259 Health Policy, 139/2844 Medicine (miscellaneous) No data IDR 2018 UEM
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-09-09 | Journal of the American Medical Directors Association |