6533b83afe1ef96bd12a7012

RESEARCH PRODUCT

Alteration of the Mitochondrial Effects of Ceria Nanoparticles by Gold: An Approach for the Mitochondrial Modulation of Cells Based on Nanomedicine

Patricia Gutiérrez-carcedoSergio NavalónRafael Simó CanongeXavier SetoainCarolina Aparicio-gómezIbane AbasoloVictor Manuel VictorHermenegildo GarcíaJosé Raúl HeranceUniversitat Autònoma De Barcelona

subject

AntioxidantantioxidantGeneral Chemical Engineeringmedicine.medical_treatmentNanoparticleceria nanoparticles02 engineering and technologyMitochondrionmedicine.disease_causeArticlelcsh:Chemistry03 medical and health scienceschemistry.chemical_compoundQUIMICA ORGANICAmitochondrial functionmedicineGeneral Materials ScienceNRF1Gold-supported ceria nanoparticles030304 developmental biology0303 health sciencesChemistryfungigold-supported ceria nanoparticlesfood and beveragestriphenylphosphonium gold-supported ceria nanoparticles021001 nanoscience & nanotechnologylcsh:QD1-999Colloidal goldBiophysicsNanomedicineMitochondrial functionAntioxidant0210 nano-technologyAdenosine triphosphateCeria nanoparticlesOxidative stressTriphenylphosphonium gold-supported ceria nanoparticles

description

Ceria nanoparticles are cell compatible antioxidants whose activity can be enhanced by gold deposition and by surface functionalization with positive triphenylphosphonium units to selectively target the mitochondria. The antioxidant properties of these nanoparticles can serve as the basis of a new strategy for the treatment of several disorders exhibiting oxidative stress, such as cancer, diabetes or Alzheimer&rsquo

yearjournalcountryeditionlanguage
2020-04-01
10.3390/nano10040744https://hdl.handle.net/10251/176235