6533b83afe1ef96bd12a7024

RESEARCH PRODUCT

Effect of acidosis on lipid peroxidation in brain slices.

Jean BraletChristine BouvierMicheline BoquillonLisbeth Schreiber

subject

Malemedicine.medical_specialtyIn Vitro TechniquesPhosphatesLipid peroxidationchemistry.chemical_compoundSlice preparationInternal medicinemedicineAnimalsCytotoxicityMolecular BiologyIncubationAcidosisCerebral CortexChemistryGeneral NeuroscienceBrainRats Inbred StrainsMetabolismHydrogen-Ion Concentrationmedicine.diseaseLactic acidRatsKineticsEndocrinologyBiochemistryLactic acidosisLactatesNeurology (clinical)Lipid Peroxidationmedicine.symptomAcidosisDevelopmental Biology

description

Acidification of the incubation medium markedly increased lipid peroxidation of cortical brain slices. Lactic acidosis caused a more extensive lipid peroxidation than did phosphoric acidosis (+35% at pH 6 and +81% at pH 5), probably due to the rapid diffusion of the protonated form of lactic acid across cell membranes. These results support the hypothesis that free radical mechanisms may be involved in the cytotoxicity of acidosis.

yearjournalcountryeditionlanguage
1991-01-18Brain research
10.1016/0006-8993(91)90703-xhttps://pubmed.ncbi.nlm.nih.gov/2015500