Synthesis of trifluoromethyl-substituted 1,2,6-thiadiazine 1-oxides from sulfonimidamides under mechanochemical conditions

6533b83afe1ef96bd12a7071

RESEARCH PRODUCT

Synthesis of trifluoromethyl-substituted 1,2,6-thiadiazine 1-oxides from sulfonimidamides under mechanochemical conditions

Marco Thomas Passia Jan-hendrik Schöbel Kari Rissanen Carsten Bolm Niklas Julian Lentelink Khai-nghi Truong

subject

chemistry.chemical_compound Trifluoromethyl Chemistry Organic Chemistry Organic chemistry Physical and Theoretical Chemistry Biochemistry Value (mathematics)

description

TBS-protected or NH-sulfonimidamides react with β-alkoxyvinyl trifluoromethylketones under solvent-free mechanochemical conditions to give 3-trifluoromethyl-substituted three-dimensional 1,2,6-thiadiazine 1-oxides. C4-Functionalized products can be obtained by starting from cyclic enones and brominations of the initially formed heterocycles. The stability of the products was investigated by varying the pH value and storage under aerobic conditions.

year	journal	country	edition	language
2021-10-29	Organic & Biomolecular Chemistry

https://doi.org/10.1039/d1ob01912k

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