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RESEARCH PRODUCT
Red blood cell deformability in multiple myeloma1.
Gregorio CaimiMelania CarlisiMaria MontanaRosalia Lo PrestiEugenia HoppsEleonora GallàSergio Siragusasubject
Malemedicine.medical_specialtyPhysiology030204 cardiovascular system & hematologyMicrocirculation03 medical and health sciences0302 clinical medicinePhysiology (medical)Internal medicineErythrocyte DeformabilitymedicineErythrocyte deformabilityHumansPlasma viscosityMultiple myelomaAgedHematologyChemistryMicrocirculationHematologyVenous bloodmedicine.diseaseMicrocirculatory flowRed blood cellmedicine.anatomical_structureEndocrinology030220 oncology & carcinogenesisFemaleCardiology and Cardiovascular MedicineMultiple Myelomadescription
The aim of this study was the evaluation of the erythrocyte deformability in multiple myeloma (MM). We enrolled 29 MM patients and we evaluated, on fasting venous blood, the erythrocyte deformability, expressed as elongation index, and examined using the diffractometric method. By comparing normal controls and MM patients, a significant decrease in erythrocyte deformability, especially at low shear stresses, was found. In this research paper we evaluated all the hypothesis for a possible explanation of the behaviour of red blood cell deformability in MM, even considering how the alteration of erythrocyte deformability worsens the microcirculatory flow in these patients in association with the marked increase in plasma viscosity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-04-10 | Clinical hemorheology and microcirculation |