6533b83afe1ef96bd12a714f
RESEARCH PRODUCT
Exploiting Palladium-Catalyzed Cross-Coupling for the Synthesis of 2-Aryl-Substituted 1-Aminocyclopropylphosphonates
Stéphane BrandèsAlla Bessmertnykh-lemeuneN. N. MakukhinN. N. MakukhinRoger GuilardNataliya S. GoulioukinaNataliya S. GoulioukinaIrina P. BeletskayaIrina P. Beletskayasubject
CouplingChemistryArylOrganic Chemistrychemistry.chemical_elementBond formationPhosphonateCombinatorial chemistryCatalysisCatalysischemistry.chemical_compoundYield (chemistry)Organic chemistry[CHIM]Chemical SciencesComputingMilieux_MISCELLANEOUSPalladiumdescription
A series of 2-aryl-substituted 1-aminocyclopropylphosphonates containing an additional remote phosphonate group have been synthesized starting from readily accessible dimethyl (1 R *,2 R *)-2-(4-bromophenyl)-1-formamidocyclopropylphosphonate using cross-coupling methodology. Different types of palladium-catalyzed reactions for carbon–carbon and carbon–phosphorus bond formation were realized. In each case the optimum conditions were found to obtain the desired products in high yield in both small- and large-scale experiments.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-05 |