6533b83afe1ef96bd12a720a

RESEARCH PRODUCT

Anticonvulsants do not suppress long-term potentiation (LTP) in the rat hippocampus

Susanne BirnstielHelmut L. Haas

subject

MaleMidazolammedicine.medical_treatmentPopulationHippocampusIn Vitro TechniquesPharmacologyNeurotransmissionHippocampusLTP inductionmedicineAnimalseducationEvoked Potentialsgamma-Aminobutyric Acideducation.field_of_studyChemistryGeneral NeuroscienceRats Inbred StrainsLong-term potentiationRatsAnticonvulsantnervous systemPhenytoinSynapsesNMDA receptorAnticonvulsantsFemaleTetanic stimulation

description

Long-term potentiation (LTP) of population spikes in the CA1 area of rat hippocampus was induced by tetanic stimulation of stratum radiatum in slices kept submerged in a perfusion chamber. Addition of the two antiepileptic drugs phenytoin or the diazepine midazolam to the medium did not significantly alter this phenomenon within 22 min after the tetanus. The early enhancement (post-tetanic potentiation, PTP) was reduced only by phenytoin. Therefore an interaction of these drugs with N-methyl-D-aspartate (NMDA) receptors and LTP induction is unlikely.

yearjournalcountryeditionlanguage
1991-01-14Neuroscience Letters
https://doi.org/10.1016/0304-3940(91)90193-w