6533b83afe1ef96bd12a780a

RESEARCH PRODUCT

Pigmented desmoplastic trichilemmoma

Carlos MonteagudoCarolina Martínez-ciarpaglini

subject

Basement membranePathologymedicine.medical_specialtyHistologyPigmented basal cell carcinomaTrichilemmomaInvasive carcinomaDermatologyDesmoplastic trichilemmomaBiologymedicine.diseaseOuter root sheathPathology and Forensic Medicine030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicinemedicine.anatomical_structure030220 oncology & carcinogenesisPeripheral Nuclear PalisadingmedicineDifferential diagnosis

description

Desmoplastic trichilemmoma (DT), the pseudomalignant variant of conventional trichilemmoma described by Hunt et al in 1990, displays a superficial lobular growth pattern of glycogen-rich cells with peripheral nuclear palisading surrounded by a thickened basement membrane. DT differs from its conventional counterpart by showing a central hyalinized area with epithelial cords and strands mimicking invasive carcinoma. We report a case that fully satisfies the criteria for DT and, in addition, shows an extensive melanocytic cell component and prominent melanin deposition. To our knowledge, a pigmented variant of DT has not been reported and should be recognized in order to appropriately face the differential diagnosis with malignant pigmented tumors particularly pigmented basal cell carcinoma (BCC).

yearjournalcountryeditionlanguage
2016-04-15Journal of Cutaneous Pathology
https://doi.org/10.1111/cup.12694