6533b83afe1ef96bd12a7816

RESEARCH PRODUCT

Pain killer without a high

Beat LutzKrisztina Monory

subject

Traditional medicinebusiness.industryMedicinelipids (amino acids peptides and proteins)General MedicinePharmacologyReceptorbusinessGeneral Biochemistry Genetics and Molecular BiologyEndogenous opioidPeripheral

description

THC acts as a pain reliever in part by engaging a receptor in peripheral tissues, CB2. But exactly where CB2 is and how it operates has been unclear. A new study shows that cannabinoids, acting through CB2 on skin cells, stimulate the local release of endogenous opioids.

https://doi.org/10.1038/nm0405-378