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RESEARCH PRODUCT
A [13]rotaxane assembled via a palladium molecular capsule
Richard E. P. WinpennyIñigo J. Vitorica-yrezabalGrigore A. TimcoGeorge F. S. WhiteheadDeepak AsthanaChristopher A. MurynFloriana TunaSelina NawazJesús Ferrando-soriaJesús Ferrando-soriaAntonio FernandezAntonio FernandezNeil D. Burtonsubject
0301 basic medicineMaterials scienceRotaxaneScienceInterlocked moleculesSupramolecular chemistryGeneral Physics and Astronomychemistry.chemical_elementNanotechnology02 engineering and technologyGeneral Biochemistry Genetics and Molecular BiologyNanocapsulesArticleMetal03 medical and health sciencesMolecular dynamicsMoleculelcsh:ScienceMultidisciplinaryMolecular capsulesQGeneral Chemistry021001 nanoscience & nanotechnologyCharacterization (materials science)030104 developmental biologychemistryvisual_artvisual_art.visual_art_mediumlcsh:Q0210 nano-technologyPalladiumdescription
Molecules that are the size of small proteins are difficult to make. The most frequently examined route is via self-assembly, and one particular approach involves molecular nanocapsules, where ligands are designed that will enforce the formation of specific polyhedra of metals within the core of the structure. Here we show that this approach can be combined with mechanically interlocking molecules to produce nanocapsules that are decorated on their exterior. This could be a general route to very large molecules, and is exemplified here by the synthesis and structural characterization of a [13]rotaxane, containing 150 metal centres. Small angle X-ray scattering combined with atomistic molecular dynamics simulations demonstrate the compound is intact in solution.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-08-01 | Nature Communications |