6533b83afe1ef96bd12a7ac4
RESEARCH PRODUCT
Synthesis, characterization, and crystal structure of [Cu(cinoxacinate)2] · 2H2O complex: A square-planar CuO4 chromophore. Antibacterial studies
E CantónR. OrtizL. PerellóAlfonso CastiñeirasM. RuizCäcilia Maichle-mössmersubject
Spectrophotometry InfraredStereochemistryCrystal structureMicrobial Sensitivity TestsCrystallography X-RayBiochemistryInorganic ChemistryCrystalchemistry.chemical_compoundEnterobacteriaceaeOrganometallic CompoundsMoleculeCarboxylateGroup 2 organometallic chemistryGram-Negative Aerobic BacteriaMolecular StructureChemistryLigandSpectrophotometry AtomicElectron Spin Resonance SpectroscopyChromophoreGram-Positive CocciSolubilityCinoxacinSpectrophotometry UltravioletCopperMonoclinic crystal systemdescription
The structural and spectroscopic properties of a new copper (II) complex of cinoxacin (HCx) have been investigated. The complex [Cu(Cx)2].2H2O crystallizes in the monoclinic system, space group P2(1)/c. The cell dimensions are: a = 7.998(2), b = 7.622(1), c = 18.955(6) A, beta = 94.38(2) degree, V = 1154.6(6) A3, Z = 2. The structure was refined to R = 0.051. The crystal is composed of [Cu(Cx)2] units and uncoordinated water molecules. The Cu(II) ion, at a center of symmetry, is coordinated to two cinoxacinate (Cx) ligands related by the inversion center. Each cinoxacinate acts as bidentate ligand bonded to the cation through its carboxylate oxygen atom and through its exocyclic carbonyl oxygen atom, resulting in a CuO4 chromophore in a crystallographically planar configuration. The complex was screened for its activity against several bacteria, showing the same antimicrobial activity as the corresponding ligand.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-09-01 |