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RESEARCH PRODUCT

Physical Activity, Incidence, and Progression of Age-Related Macular Degeneration: A Multicohort Study.

Matthias M. MauschitzMarie Therese SchmitzTimo VerzijdenMatthias SchmidEric F. TheeJohanna M. ColijnCécile DelcourtAudrey Cougnard-gregoireBenedicte M. J. MerleJean Francois KorobelnikBamini GopinathPaul MitchellHisham ElbazAlexander K. SchusterPhilipp S. WildCaroline BrandlKlaus J. StarkIris M. HeidFelix GuntherAnnette PetersCaroline C. W. KlaverRobert P. FingerConsortium European Eye Epidemiology

subject

Adultmedicine.medical_specialtygenetic structuresPopulationPhysical activitySensory disorders Donders Center for Medical Neuroscience [Radboudumc 12]Cohort Studies03 medical and health sciencesMacular Degeneration0302 clinical medicineSDG 3 - Good Health and Well-beingRisk FactorsInternal medicineAge relatedmedicineHumansLongitudinal StudiesRisk factoreducationExerciseAgededucation.field_of_studybusiness.industryIncidence (epidemiology)IncidenceHazard ratioMacular degenerationMiddle Agedmedicine.diseaseeye diseases3. Good healthOphthalmology030221 ophthalmology & optometryDisease Progression[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologiesense organsbusiness030217 neurology & neurosurgeryCohort studyFollow-Up Studies

description

Contains fulltext : 249581.pdf (Publisher’s version ) (Closed access) PURPOSE: To investigate the impact of physical activity (PA) on the incidence or progression of age-related macular degeneration (AMD) in the general population. DESIGN: Meta-analysis of longitudinal cohort studies. METHODS: We included 14,630 adults with no or early AMD at baseline from 7 population-based studies and examined associations of PA with AMD incidence and progression using multistate models (MSM) per study and subsequent random effects meta-analysis. Age effects were assessed using meta-regression. The main outcome measure was the hazard ratio (HR) for incident early or progression to late AMD. RESULTS: At baseline, mean age was 60.7 ± 6.9 to 76.4 ± 4.3 years, and prevalence of early AMD was 7.7% (range, 3.6%-16.9%) between cohorts. During follow-up, 1461 and 189 events occurred for early and late AMD, respectively. In meta-analyses, no or low to moderate PA (high PA as reference) was associated with an increased risk for incident early AMD (HR, 1.19; 95% CI, 1.01-1.40; P = .04), but not for late AMD. In subsequent meta-regression, we found no association of age with the effect of PA on incident AMD. CONCLUSIONS: Our study suggests high levels of PA to be protective for the development of early AMD across several population-based cohort studies. Our results establish PA as a modifiable risk factor for AMD and inform further AMD prevention strategies to reduce its public health impact. 01 april 2022

yearjournalcountryeditionlanguage
2022-04-01
10.1016/j.ajo.2021.10.008http://hdl.handle.net/2066/249581