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RESEARCH PRODUCT
Bone Marrow Findings in Multicentric Castleman Disease in HIV-negative Patients
Andreas KreftErik SpringerCharles James KirkpatrickGeorg HessAchim Webersubject
AdultMalemedicine.medical_specialtyPathologyBone Marrow CellsPlasma cellPathology and Forensic MedicineImmune systemBone MarrowHIV SeronegativityImmunopathologymedicineHumansAntigens ViralAgedbusiness.industryCastleman DiseaseCastleman diseasePlasmacytosisvirus diseasesGerminal centerAnatomical pathologyHerpesviridae InfectionsMiddle AgedGerminal Centermedicine.diseasemedicine.anatomical_structureDNA ViralHerpesvirus 8 HumanImmunologyFemaleSurgeryLymph NodesBone marrowAnatomybusinessdescription
Because bone marrow histology in multicentric Castleman disease in human immunodeficiency virus-negative patients is not well reported, we investigated sequential bone marrow biopsies of 3 affected human immunodeficiency virus-negative patients, of which one was human herpes virus 8 (HHV8)-positive. The histologic evaluation of the bone marrow revealed lymphoid follicles with regressed germinal centers in 1 patient. Another patient showed tumorlike but bland polyclonal plasmacytosis with large perivascular plasma cell clusters. The HHV8-positive patient revealed interstitial HHV8-positive cells accompanied by a mild plasmacytosis. The atypical lymphoid follicles could be regarded as a bone marrow manifestation of multicentric Castleman disease, whereas the plasmacytosis most likely is the result of excess interleukin 6 production. The presence of HHV8-positive cells within the bone marrow may indicate the dissemination of the virus in a compromised immune system.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-03-01 | American Journal of Surgical Pathology |