6533b83afe1ef96bd12a7bab
RESEARCH PRODUCT
Longitudinally extensive transverse myelitis with AQP4 antibodies revealing ovarian teratoma.
José Manuel García-verdugoMarina FrasquetBonaventura CasanovaMaría Simó-castellóMaria Duran-morenoTeresa SevillaSalvador RivasLuis BatallerEstefanía Torres-vegaFrancisco Pérez-mirallessubject
AdultPathologymedicine.medical_specialtyImmunologyLymphoproliferative disordersMyelitis TransverseAutoimmune diseases Paraneoplastic syndrome Transverse myelitisTransverse myelitisDiagnosis DifferentialmedicineImmunology and AllergyHumansNeurociènciesOvarian TeratomaAutoantibodiesAquaporin 4Ovarian Neoplasmsbiologybusiness.industryParaneoplastic MyelitisTeratomamedicine.diseaseNeurologybiology.proteinRituximabFemaleSistema nerviós MalaltiesNeurology (clinical)TeratomaAntibodybusinessBiomarkersmedicine.drugInflammatory disorderdescription
Paraneoplastic myelitis is a rare inflammatory disorder most frequently associated with solid tumors or lymphoproliferative disorders. Patients often harbor onconeuronal antibodies and their prognosis is usually poor. Here we report a 42-year old woman with longitudinally extensive transverse myelitis and aquaporin-4 (AQP4) antibodies that led to the diagnosis of ovarian teratoma. After tumor removal and immune therapy (including corticosteroids, plasma exchange, intravenous immunoglobulins and rituximab) the patient progressively improved achieving complete recovery. Histological study of the teratoma demonstrated neural tissue containing AQP4 expressing cells and intense inflammatory infiltrates, providing evidence for a possible paraneoplastic link between both disorders.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-01 |