6533b83afe1ef96bd12a7bbb
RESEARCH PRODUCT
Polymeric nanoparticles for siRNA delivery: Production and applications
Gennara CavallaroCarla SardoEmanuela Fabiola CraparoGaetano GiammonaBarbara Porsiosubject
siRNA deliveryPolymersPharmaceutical ScienceNanotechnology02 engineering and technologyPolyethylenimine010402 general chemistry01 natural scienceschemistry.chemical_compoundPolyaminesHumansRNA Small InterferingPolyethylenimineChitosanPolymeric non viral vectorInulinChitosan; Inulin; Polyaspartamide; Polyethylenimine; Polymeric non viral vectors; siRNA delivery.Genetic Therapy021001 nanoscience & nanotechnologyPolymeric nanoparticles0104 chemical sciencesClinical PracticePolyaspartamidechemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoPolymeric non viral vectorsNanoparticles0210 nano-technologyPeptidessiRNA delivery.description
Gene therapy through the use of siRNA and a polymeric carrier are becoming an efficient therapeutic option to conventional pharmaceutical formulations for the treatment of deadly diseases, such as cancer, pulmonary, ocular and neurodegenerative diseases. However, several considerations regarding the stability, formulation, and efficacy have to be faced up until these systems could be considered to be a marketable pharmaceutical products for to extend siRNA application to clinical practice. This review is focused on the key challenges of siRNA therapeutics, with special attention on the faced obstacles and on the formulation-related difficulties, providing a list of requirements needed for obtaining an ideal carrier for siRNA. Moreover, the current non-viral polymers investigated for the realization of efficient carriers for siRNA are described, with a special attention on synthetic polyamines such as polyethylenimine (PEI), polysaccharides such as chitosan and inulin (INU), and polyaminoacids such as α,β-poly(N-2-hydroxyethyl)-d,l-aspartamide (PHEA) and poly-L-lysine (PLL).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-06-20 |