ChemInform Abstract: Synthesis of a Naphtho-pyrido-Annulated Iodonium Salt and Pd-Catalyzed Transformation to 7H-Naphtho[1,8-bc][1,5]naphthyridine.

6533b850fe1ef96bd12a81e3

RESEARCH PRODUCT

ChemInform Abstract: Synthesis of a Naphtho-pyrido-Annulated Iodonium Salt and Pd-Catalyzed Transformation to 7H-Naphtho[1,8-bc][1,5]naphthyridine.

Julien Letessier Dieter Schollmeyer Mario Geffe Heiner Detert

subject

chemistry.chemical_classification Transformation (genetics)Chemistry Nitro Organic chemistry Salt (chemistry)General Medicine Amination Catalysis

description

Nitropyridylnaphthalene is the central intermediate for the synthesis of naphthonaphthyridine and benzo-δ-carboline. Whereas the Cadogan reaction gives the carboline, transformation of the nitro group to iodo followed by oxidation and cyclization results in an iodonium salt. A twofold Pd-catalyzed amination leads to the naphthyridine.

year	journal	country	edition	language
2014-04-17	ChemInform

https://doi.org/10.1002/chin.201418160

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