Designing a Transition State Analogue for the Disfavored Intramolecular Michael Addition of 2-(2-Hydroxyethyl)acrylate Esters

6533b850fe1ef96bd12a8239

RESEARCH PRODUCT

Designing a Transition State Analogue for the Disfavored Intramolecular Michael Addition of 2-(2-Hydroxyethyl)acrylate Esters

subject

chemistry.chemical_compound Addition reaction Acrylate Transition state analog Chemistry Intramolecular force Organic Chemistry Polymer chemistry Michael reaction Organic chemistry 2-HYDROXYETHYL ACRYLATE Tetrahydrofuran

description

The rate-determining steps for the intramolecular 1,2 and 1,4 addition reactions in basic medium of methyl 2-(2-hydroxyethyl)acrylate to give the corresponding γ-lactone and tetrahydrofuran, respec...

year	journal	country	edition	language
1999-11-19	The Journal of Organic Chemistry

https://doi.org/10.1021/jo991117c

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