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RESEARCH PRODUCT

Immunophenotype in orofacial granulomatosis with and without Crohn's disease

Gita GaleRobert SaalmanBengt HasséusSofia ÖStmanMats JontellEsbjörn Telemo

subject

AdultMalePathologymedicine.medical_specialtyAdolescentConnective tissueOdontologíamedicine.disease_causeImmunophenotypingAutoimmunityYoung AdultImmunophenotypingCrohn DiseaseBiopsymedicineHumansGranulomatosis OrofacialChildGeneral DentistryRetrospective StudiesCD20Crohn's diseaseOral Medicine and Pathologymedicine.diagnostic_testbiologybusiness.industryResearchMiddle Aged:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseCiencias de la saludmedicine.anatomical_structureOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASbiology.proteinFemaleSurgeryOrofacial granulomatosisbusinessCD8

description

Objectives: The aim of this investigation was to characterise and compare the inflammatory infiltrates in patients with orofacial granulomatosis solely (OFG-S) and OFG with coexisting Crohn’s disease (OFG+CD). Study Design: Biopsy specimens with granulomas were obtained from patients with OFG-S (n=11) and OFG+CD (n=11) and immunostained with antibodies against CD1a, CD3, CD4, CD8, CD11c, CD20, CD68 and mast cell tryptase, followed by quantitative analysis. Results: Analyses of the connective tissue revealed a significantly higher number of CD3-expressing T cells and CD11c-expressing dendritic cells in the connective tissue of patients with OFG-S compared to patients with OFG+CD. Mast cells displayed a high level of activation, although no significant difference was detected when comparing the two groups. Conclusions: The results show a different composition of the inflammatory infiltrate in patients with OFG-S compared to patients with OFG+CD. The present observations support that partly divergent immune mechanisms are involved in these two different subcategories of OFG. Key words:Granulomas, autoimmunity, T cells, B cells, dendritic cells, children, adults.

yearjournalcountryeditionlanguage
2014-05-22
http://hdl.handle.net/10550/41155