6533b850fe1ef96bd12a836d

RESEARCH PRODUCT

From Small Peptides to Large Proteins against Alzheimer'sDisease.

Pasquale PiconeTiziana SanfilippoSonya VastoSara BaldassanoRossella GugginoDomenico NuzzoDonatella BulonePier Luigi San BiagioEmanuela MuscolinoRoberto MonasteroClelia DispenzaDaniela Giacomazza

subject

NeuronsAmyloid beta-Peptidesamyloid-beta protein: amyloid fibrillationAlzheimer DiseaseTau proteinHumanstau ProteinsPlaque AmyloidNeurofibrillary TanglesMolecular BiologyBiochemistryAlzheimer’s diseaseAged

description

Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the elderly. The two cardinal neuropathological hallmarks of AD are the senile plaques, which are extracellular deposits mainly constituted by beta-amyloids, and neurofibrillary tangles formed by abnormally phosphorylated Tau (p-Tau) located in the cytoplasm of neurons. Although the research has made relevant progress in the management of the disease, the treatment is still lacking. Only symptomatic medications exist for the disease, and, in the meantime, laboratories worldwide are investigating disease-modifying treatments for AD. In the present review, results centered on the use of peptides of different sizes involved in AD are presented.

yearjournalcountryeditionlanguage
2022-10-22Biomolecules
10.3390/biom12101344https://pubmed.ncbi.nlm.nih.gov/36291553