6533b850fe1ef96bd12a836e

RESEARCH PRODUCT

Fatal cerebellar haemorrhage due to phenprocoumon poisoning.

J. BeckerCh. RittnerK H Meyer Zum BüschenfeldeThomas Höhler

subject

VitaminAdultMalemedicine.medical_specialtyBrain DeathPoison controlGastroenterologyPathology and Forensic MedicinePhenprocoumonchemistry.chemical_compoundCerebellar DiseasesInternal medicineVitamin K deficiencyMedicineHumansCause of deathCerebral HemorrhageClotting factorDose-Response Relationship Drugbusiness.industryWarfarinBrainmedicine.diseaseSurgerychemistryPhenprocoumonVitamin K DeficiencyBlood Coagulation TestsDifferential diagnosisDrug Overdosebusinessmedicine.drug

description

A 32-year-old patient died of a cerebellar haemorrhage and the blood coagulation analysis before death suggested defective synthesis of vitamin K-dependent clotting factors due to vitamin K deficiency. The post-mortem toxicological examination of different tissues revealed phenprocoumon poisoning as the cause of death. The differential diagnosis of vitamin K deficiency and the toxicology of hydroxycoumarins are discussed.

10.1007/bf01369825https://pubmed.ncbi.nlm.nih.gov/8721430