6533b850fe1ef96bd12a8458
RESEARCH PRODUCT
"Writing biochips": high-resolution droplet-to-droplet manufacturing of analytical platforms.
Daniele GulliBruno Giuseppe PignataroCaterina AlfanoGiuseppe Arrabitosubject
PolymersWritingtechnology industry and agricultureBiosensing TechniquesBiochemistryAnalytical Chemistrybody regionsprintingLab-On-A-Chip Devicesparasitic diseasesPrinting Three-DimensionalElectrochemistryEnvironmental ChemistrySettore CHIM/01 - Chimica Analiticamicrocantilever spottingmicroarraycapillary stampingSpectroscopycirculatory and respiratory physiologydescription
The development of high-resolution molecular printing allows the engineering of analytical platforms enabling applications at the interface between chemistry and biology, i.e. in biosensing, electronics, single-cell biology, and point-of-care diagnostics. Their successful implementation stems from the combination of large area printing at resolutions from sub-100 nm up to macroscale, whilst controlling the composition and the volume of the ink, and reconfiguring the deposition features in due course. Similarly to handwriting pens, the engineering of continuous writing systems tackles the issue of the tedious ink replenishment between different printing steps. To this aim, this review article provides an unprecedented analysis of the latest continuous printing methods for bioanalytical chemistry, focusing on ink deposition systems based on specific sets of technologies that have been developed to this aim, namely nanofountain probe, microcantilever spotting, capillary-based polymer pens and continuous 3D printing. Each approach will be discussed revealing the most important applications in the field of biosensors, lab-on-chips and diagnostics.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-03-28 | The Analyst |