6533b850fe1ef96bd12a8474

RESEARCH PRODUCT

SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 7-SUBSTITUTED1-ETHYL-3,4,10-TRIMETHYL-1,10-DIHYDRO-11H-PYRAZOLO(3,4-c)(1,6)BENZODIAZOCIN-11-ONE: A NEW RING SYSTEM

Salvatore PlesciaDall'olio RDi StefanoVita Di StefanoPatrizia DianaMigliara OCamarda LDiana POnofrio MigliaraLorenzo CamardaPlescia S

subject

lcsh:QD241-441chemistry.chemical_compoundlcsh:Organic chemistryChemistryStereochemistryYield (chemistry)Organic ChemistryMoietyPyrazoleRing (chemistry)Anxiolytic agents

description

Derivatives of the title ring system of type 10 were obtained in good yield by fusion of the intermediates 12. Attempt to cyclize the acetylamino derivative 9 under Bischler-Napieralski conditions failed because of the insufficient electronic density in the position 4 of the pyrazole ring created by the adjacent carbonyl moiety. The derivatives of the new ring system, assayed as anxiolytic agents, showed no significant activity.

yearjournalcountryeditionlanguage
2004-01-15
http://hdl.handle.net/10447/4636