6533b850fe1ef96bd12a8613

RESEARCH PRODUCT

Steroidal saponins from Smilax medica and their antifungal activity.

Marie Aleth Lacaille-duboisMarc SautourTomofumi Miyamoto

subject

Antifungal AgentsStereochemistrySaponinPharmaceutical ScienceMicrobial Sensitivity TestsPharmacognosyAnalytical ChemistryDrug DiscoveryHumansCandida albicansMexicoNuclear Magnetic Resonance BiomolecularCandidaPharmacologychemistry.chemical_classificationPlants MedicinalbiologyTraditional medicineCandida glabrataMolecular StructureLiliaceaeOrganic ChemistrySmilaxGlycosideBiological activitySaponinsbiology.organism_classificationComplementary and alternative medicinechemistrySmilaxMolecular MedicineSteroids

description

Three new steroidal saponins (1-3) were isolated from the roots of Smilax medica, together with the known disporoside A (4). The structures of the new compounds were elucidated mainly by extensive spectroscopic analysis (1D and 2D NMR, FABMS, and HRESIMS). Compounds 1, 2, and 4 demonstrated weak antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata, and C.tropicalis, with MIC values between 12.5 and 50 microg/mL.

yearjournalcountryeditionlanguage
2005-09-15Journal of natural products
10.1021/np058060bhttps://pubmed.ncbi.nlm.nih.gov/16252913