6533b851fe1ef96bd12a8ca1
RESEARCH PRODUCT
Addition of α-Aminonitriles to α,β-Unsaturated Carbonyl Compounds: A One-Pot Synthesis of Polysubstituted Pyrrolidines.
Till OpatzNino Meyersubject
chemistry.chemical_compoundDeprotonationchemistryReaction sequenceOne-pot synthesisSubstituentOrganic chemistryGeneral MedicinePyrrole derivativesCarbaniondescription
The vinylogous addition of deprotonated N-alkyl-α-aminonitriles to α,β-unsaturated carbonyl compounds yields cyclic intermediates which can be reduced to form polysubstituted pyrrolidines in a one-pot reaction sequence. Since the cyano substituent is lost in the reduction step, the aminonitriles serve as easily accessible (N-alkylamino)-substituted carbanion equivalents.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-12-09 | ChemInform |