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RESEARCH PRODUCT
Microwave-Induced Hyperthermia and Cytostatic Agent for Superficial Bladder Cancer
M. Pavone MacalusoCarlo PavoneVincenzo SerrettaA. GaluffoMarco VellaA. Ruggirellosubject
Hyperthermiabusiness.industryToxicitySuperficial bladder cancerCancer researchMedicineThermo chemotherapyIn patientGeneral Medicinebusinessmedicine.diseasedescription
The efficacy and local toxicity of the intravesical combination of microwave-induced hyperthermia with a cytostatic agent in patients affected by superficial bladder cancer is presented. Between 1994 and 2002, two studies were performed on ablative and adjuvant intravesical thermo-chemotherapy. The ablative study demonstrated complete tumor eradication in 88% of patients who should have undergone cystectomy due to diffuse multiple papillary tumors non-responsive TUR and intravescical adjuvant therapy. In a randomized study, comparing adjuvant thermo-chemotherapy vs. standard chemotherapy with mitomycin C, recurrence-free survival analysis at 24 months revealed a significant difference in favor of thermo-chemotherapy. Our preliminary experience confirmed that local side effects, mainly cystitis, suprapubic pain and thermal reaction of the posterior bladder wall, were transitory and did not require treatment interruption.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-10-01 | Urologia Journal |