6533b851fe1ef96bd12a8d1b

RESEARCH PRODUCT

Treatment of patients with duodenal ulcer positive for helicobacter pylori infection: ranitidine or omeprazole associated with colloidal bismuth subcitrate plus amoxicillin

subject

description

Abstract This study evaluated treatment of patients affected with duodenal ulcer positive for Helicobacter pylori . We compared patients treated with ranitidine plus amoxicillin plus colloidal bismuth subcitrate (n = 20) with patients treated with omeprazole plus amoxicillin plus colloidal bismuth subcitrate (n = 20) with regard to: (1) healing of duodenal ulcer; (2) eradication of H pylori ; and (3) recurrence of ulcer. Baseline and follow-up for 24 months were performed through clinical, laboratory, and endoscopic tests. The ulcer healing rate was 95% in the ranitidine group and 100% in the omeprazole group; the H pylori eradication rate was 90% and 95%, respectively. During follow-up, only 3 patients (16%) in the ranitidine group and 2 patients (10%) in the omeprazole group had recurrence of duodenal ulcer; only 1 patient in each group showed reinfection with H pylori . In conclusion, there were no statistically significant differences between treatment with ranitidine or omeprazole, with regard to ulcer healing rate, eradication of H pylori , or recurrence of duodenal ulcer.