6533b851fe1ef96bd12a8d9f
RESEARCH PRODUCT
Activity of superoxide dismutase copper/zinc type and prognosis in a cohort of patients with coronary artery disease.
K.j. LacknerRenate B. SchnabelChristoph SinningChristoph BickelStefan BlankenbergTanja ZellerElvin ZenginDirk WestermannHans-j. Rupprechtsubject
Malemedicine.medical_specialtyClinical BiochemistryIschemiaCoronary Artery Diseasemedicine.disease_causeGastroenterologyCoronary artery diseaseSuperoxide dismutaseInternal medicineDrug DiscoverymedicineHumansIn patientAgedchemistry.chemical_classificationReactive oxygen speciesbiologybusiness.industrySuperoxide DismutaseBiochemistry (medical)Middle Agedmedicine.diseaseSurgerychemistryCohortbiology.proteinFemalebusinessReperfusion injuryOxidative stressBiomarkersFollow-Up Studiesdescription
Aim: Superoxide dismutase (SOD) is important to control reactive oxygen species, but the relevance to human disease like coronary artery disease (CAD) and underlying ischemia/reperfusion injury is not clarified. Methods: For this study, 2239 patients with known CAD were prospectively followed with a median follow-up time period of 3.6 years and a maximum of 6.9 years. During follow-up cardiovascular death was reported in 103 cases. Results: SOD activity (log-transformed) was investigated as continuous and categorical variable, showing a significant influence on outcome in the fully adjusted model (p = 0.045). Conclusion: Increased SOD activity beyond the normal range in the human physiology is related to an adverse outcome in patients with CAD.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-06-01 | Biomarkers in medicine |