Chemical sympathectomy and clorgyline-induced stimulation of rat pineal melatonin synthesis

6533b851fe1ef96bd12a8ef5

RESEARCH PRODUCT

Chemical sympathectomy and clorgyline-induced stimulation of rat pineal melatonin synthesis

St. Reuss Gregory F. Oxenkrug

subject

Male Clorgyline Serotonin medicine.medical_specialty Monoamine oxidase Stimulation Biology Pineal Gland 5-Hydroxytryptophan Melatonin Clorgyline Internal medicine medicine Animals Clorgiline Biological Psychiatry Melatonin Sympathectomy Chemical Rats Inbred Strains Hydroxyindoleacetic Acid Rats Psychiatry and Mental health Endocrinology Neurology biology.protein Antidepressant Neurology (clinical)Serotonin Monoamine oxidase A medicine.drug

description

The response to administration of the specific monoamine oxidase A (MAO-A) blocker clorgyline was investigated in adult male Sprague-Dawley rats which were sympathectomized by injection of the false neurotransmitter 6-hydroxydopamine as newborns. In intact animals which served as controls, the contents of pineal indoles melatonin, serotonin, 5-hydroxytryptophan were augmented, and the content of 5-hydroxyindoleacetic acid decreased 90 min following clorgyline injections when compared to saline receiving rats. Sympathectomized animals exhibited similar responses but these were less pronounced. It is suggested that blocking of the oxidation of both MAO-A substrates, noradrenaline and serotonin, upon clorgyline administration results in the observed increase in melatonin synthesis which is thought to contribute to the antidepressant effects of MAO inhibition.

year	journal	country	edition	language
1989-06-01	Journal of Neural Transmission

https://doi.org/10.1007/bf01252502

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