Search results for "Clorgiline"

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Chemical sympathectomy and clorgyline-induced stimulation of rat pineal melatonin synthesis

1989

The response to administration of the specific monoamine oxidase A (MAO-A) blocker clorgyline was investigated in adult male Sprague-Dawley rats which were sympathectomized by injection of the false neurotransmitter 6-hydroxydopamine as newborns. In intact animals which served as controls, the contents of pineal indoles melatonin, serotonin, 5-hydroxytryptophan were augmented, and the content of 5-hydroxyindoleacetic acid decreased 90 min following clorgyline injections when compared to saline receiving rats. Sympathectomized animals exhibited similar responses but these were less pronounced. It is suggested that blocking of the oxidation of both MAO-A substrates, noradrenaline and serotoni…

MaleClorgylineSerotoninmedicine.medical_specialtyMonoamine oxidaseStimulationBiologyPineal Gland5-HydroxytryptophanMelatoninClorgylineInternal medicinemedicineAnimalsClorgilineBiological PsychiatryMelatoninSympathectomy ChemicalRats Inbred StrainsHydroxyindoleacetic AcidRatsPsychiatry and Mental healthEndocrinologyNeurologybiology.proteinAntidepressantNeurology (clinical)SerotoninMonoamine oxidase Amedicine.drugJournal of Neural Transmission

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